What are polynucleotides?

Polynucleotides are the latest revolutionary tools in regenerative medicine that work on a cellular level to repair tissue and boost skin quality.

In the form of polymerised polynucleotide-based injectable gels, polynucleotides work by stimulating fibroblasts which encourages cell turnover, improves elasticity, boosts collagen production and hydrates skin thanks to powerful wound-healing polymers. 

Polynucleotides also calm inflammation and rebalance melanocyte activity to create an even and refreshed skin tone.

Polynucleotides are long chains of DNA. Sourced from salmon or trout sperm DNA, these highly purified fragments of DNA are suspended in water and available as an injectable. Different brands of polynucleotides have varying percentages of highly purified polynucleotides (PN-HPT). The Skin Nurse Northampton are pleased to offer a medical only brand; Mastelli with the ranges Plinest, Newest, Eye and Hair polynucleotides.

 How do polynucleotides work?

Once injected, the DNA fragments are slowly absorbed into your skin. Once integrated within your skin, they start signalling your skin in 3 main ways. Firstly, they stimulate fibroblast cells to multiply in number and boost their activity. As cell renewal improves, so will collagen production, hydration levels, and skin glow. Your skin becomes more resilient with improved elasticity and wrinkles start diminishing.

Secondly, they are incredible antioxidants that scavenge free radicals that would normally set off cellular damage. Thirdly, they function as wound healing agents signalling your skin to intensely repair. This helps improve scars, reduce stretch marks, and improve skin texture concerns. As it enters repair mode, your skin’s discoloration improves, leaving a more even tone. Additionally, polynucleotides produce a mild increase in volume and tightening as an overall effect.

How is the treatment done and how long do they take to work?

Polynucleotides are injected very superficially into your skin via two methods. In some cases, it may be injected with very tiny needles leaving tiny blebs on the surface. These blebs can disappear over a few hours but may remain for longer in some people.

Typically, you will not notice any benefits for a few weeks. This is because the action of polynucleotides is at the cellular level, and this takes time. Although you may notice some improvement after 2-3 weeks, the full effect is only visible at 3 months.

Where can they be injected?

Polynucleotides have been shown to improve skin texture and function at a cellular level and therefore, they are suitable for any area of the skin including the scalp for hair re-growth. We can either target small areas such as the under-eye, forehead, or mouth area or the whole face. They are effective for neck and decolletage rejuvenation tackling multiple issues. In the body, common areas are loose skin on the abdomen, above the knees, or inner arms.

Polynucleotides are often favoured for certain areas as it does not cause water retention like hyaluronic acid. In the under-eye area, polynucleotides can help improve skin strength and integrity instead of or prior to tear trough treatment with dermal fillers. It is best to have a face-to-face consultation to assess the area first to decide what course of treatment is best.

If you’re looking to improve body shape, reduce stubborn fat, and enhance skin firmness without surgery, 3D Lipo offers a tailored, non-invasive approach.

To book your consultation or ask any questions, please contact us today.